No chemical interactions between antispasticity drugs and antiepileptic drugs (AEDs) are well documented. In vitro studies of cytochrome P450 isoenzymes suggest that hepatic metabolism of AEDs (or other drugs) will not be affected by any of the well known oral antispasticity agents or their metabolites. Thus, spasticity drugs do not interact pharmacokinetically with AEDs and should not interfere with epilepsy therapy.
Nor do any of the drugs used to treat spasticity lower the seizure threshold. Rapid withdrawal or abrupt discontinuation of baclofen or benzodiazepines should be avoided, however, as these changes could provoke seizures.
Reviewed and revised May 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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