Lorazepam (Ativan) has several advantages:
Many epileptologists prefer lorazepam because of its favorable pharmacokinetics, but direct comparative studies are few. A double-blind, randomized trial found lorazepam marginally more effective than diazepam in controlling SE, with an onset of action not significantly different. Adverse effects are similar to those of diazepam, although perhaps less sudden. Lorazepam may provide 12 hours of anticonvulsant effect, but acute tolerance may reduce its maintenance value.
Reviewed and revised February 2004 by Thaddeus Walczak, MD, MINCEP® Epilepsy Care, Minneapolis, MN
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