The long-term prognosis for Lennox-Gastaut syndrome (LGS) is variable but, overall, unfavorable. Four cohort studies have followed up children with LGS over time and found that a minority of patients eventually could work normally, but 47–76% still had typical characteristics (mental retardation and treatment-resistant seizures) many years after onset and required significant help such as home care or institutionalization.43–46
Patients with symptomatic LGS had a worse prognosis. Groups particularly affected included those with:
In one report, tonic seizures became more difficult to control over time and persisted in 97.8% of the patients. Myoclonic seizures persisted in only 22.5% and atypical absence seizures persisted in 39.3% of the patients.47
Mortality rates range from 3% (mean follow-up of 8.5 years) to 7% (mean follow-up of 9.7 years).28
Reviewed and revised May 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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