Lennox-Gastaut syndrome (LGS) can be classified according to its suspected etiology as either idiopathic or symptomatic. Population-based studies have found that 22–30% of patients have idiopathic LGS and 70–78% have symptomatic LGS.21,22,27,28
Patients may be considered to have idiopathic LGS21 if:
In contrast, patients are considered to have symptomatic LGS if an identifiable factor is responsible for the syndrome. Examples of underlying pathologic processes responsible for symptomatic LGS include:20,21, 25
Some investigators consider cryptogenic LGS as a separate etiologic category, in which the epilepsy is presumed to be symptomatic but no cause is identified. In an epidemiologic study in Atlanta, 44% of all LGS patients were classified in the cryptogenic group.23
Reviewed and revised May 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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