In the immunocompromised patient, even subtle neurologic signs must prompt evaluation for possible CNS infection. In one series, 60% of immunosuppressed cancer patients died as a result of CNS infection, although many had malignancies with less-than-fatal prognoses.139,192
A presentation of new-onset seizure obviously prompts a workup. An expedited search for infection is also mandated, however, when a seizure occurs in an iatrogenically immunosuppressed cancer patient with a seizure disorder secondary to a known brain tumor (either primary or metastatic).
Reviewed and revised March 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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