Levetiracetam is rapidly and almost completely absorbed. Protein binding is <10 % and 66% of levetiracetam is excreted renally as unchanged drug. Metabolism of the remaining drug occurs by hydrolysis of the acetamide group and is not cytochrome P450 dependent.41
The clearance of levetiracetam is reported to be unaffected by liver disease.
The effect of GI disease on levetiracetam is unknown.
Reviewed March 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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