Gabapentin is rapidly absorbed, reaching a peak in 2 to 4 hours. It binds to a leucine-amino acid protein in the gut and is actively absorbed. The bioavailability of gabapentin decreases with increase in dose. It is not metabolized, is not bound to plasma proteins, and is excreted unchanged in the urine.32
Liver disease should not affect gabapentin because it is not hepatically metabolized and is not protein-bound.
It is unknown whether GI disease affects the leucine-amino protein that is responsible for the active absorption of gabapentin.
Reviewed March 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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