The objective of temporal lobe surgery in patients with drug-resistant mesial temporal lobe epilepsy (mTLE) is to resect the epileptogenic zone responsible for generating seizures. Surgical approaches vary, though amygdalohippocampectomy with and without lateral predicts a favorable seizure free outcome when electro-clinical correlation is concordant with a structural lesion1. Additional electrodes and subtemporal electrodes (ie sphenoidals) may improve source localization of the interictal spikes in mTLE. Febrile seizures during childhood can evoke neuronal atrophy and sclerosis of the hippocampus. Despite the characteristic history and non-invasive evaluation strongly favoring mTLE, our patient was not rendered seizure free after surgery. Surrounding brain regions (ie insular cortex) may propagate to the temporal lobe or mimic TLE. Other pathologies such as end folium sclerosis and amygdalar sclerosis may represent the epiphenomenon of febrile seizures or seizures of extrahippocampal origin2. Our patient has had seizures persist though they have “run down” over the last decade since surgery.
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