Only about 10% of lamotrigine is cleared by the kidney. Nevertheless, the elimination half-life of lamotrigine is increased by approximately 50% in patients with renal insufficiency. 54 The dose of lamotrigine may need to be reduced in these patients.54,55
Lamotrigine is poorly soluble in water, is approximately 50% bound to plasma proteins, and has a modest volume of distribution. In a study of 6 subjects on hemodialysis, an average of 20% (range 5.6% to 35.1%) of lamotrigine present in the body was eliminated during a 4-hour hemodialysis session.54
Reviewed and revised February 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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