Gabapentin is cleared almost entirely by glomerular filtration. Gabapentin clearance decreases in proportion to the decrease in creatinine clearance in patients with renal insufficiency.51 Following are the recommended decreases in gabapentin dosing rate as a function of decreased creatinine clearance:
|Creatinine clearance |
|Total daily dose |
|> 60||1,200||400 t.i.d.|
|< 15||150||300 q.o.d.|
Gabapentin is water soluble, has low protein binding, and has a low volume of distribution. Large amounts of gabapentin are lost during hemodialysis.52 A loading dose of 200–300 mg of gabapentin following each 4 hours of hemodialysis is recommended.51,53
Reviewed and revised February 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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