The absorption and clearance of carbamazepine do not appear to be influenced by renal impairment.42 Carbamazepine has a significant antidiuretic effect, however, and may promote fluid retention.
Carbamazepine is poorly soluble in water and is 80% protein bound. As expected, hemodialysis has little effect on carbamazepine plasma concentration.43
Reviewed and revised February 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
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