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Antidepressants	Seizure Incidence (%)
TCAs and tetracyclic antidepressants
Amitriptyline	<0.1-0.3
Amoxapine	24.5-36.4
Clomipramine	0.7-3.0
Desipramine	<0.1
Doxepin	<0.1
Imipramine	<0.1-0.9
Maprotiline	0.4-15.6
Nortriptyline	<0.1
Protriptyline	<0.1
SSRI and SNRI
Citalopram	<0.1
Fluoxetine	<0.1-0.2
Fluvoxamine	<0.2
Paroxetine	<0.1
Sertraline	<0.1
Venlafaxine	<0.26
Other antidepressants
Bupropion	0.6-1.0
>450 mg/day	0.6-2.19
SR 400 mg/day	0.4
SR 300 mg/day	0.1
Mirtazapine	<0.1
Nefazodone	NA
Trazodone	<0.1

TCAs = tricyclic antidepressants
SNRI = serotonin-norepinephrine reuptake inhibitor
SSRI = selective serotonin reuptake inhibitor
SR = sustained-release formula
NA = limited information

Adapted from: Barry JJ and Huynh N. Psychotropic drug use in patients with epilepsy and developmental disabilities. In: Devinsky O and Westbrook LE, eds. Epilepsy and Developmental Disabilities. Boston: Butterworth-Heinemann; 2001;205-217.
With permission from Elsevier (www.elsevier.com).
Reviewed and revised June 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.