Support information on page: Diagnosis & Treatment > Procedures in Epilepsy Patients > Premedication
Antiepileptic Drugs Available for Rectal Administration
||Same as oral
||Oral Suspension (dilute with equal volume of water)
Suppository gel (carba-
mzepine powder disolved in 20% alcohol and methyl hydroxy cellulose)*
|Peak concentration 4-8 hrs; 80% absorbed
||Peak concentration 0.1-2.0 hrs
||Onset may be too slow for acute use. Well tolerated.
||Effect in 2-10 mins; peak concentraion 2-30 mins
ulates with repeated doses
||Peak concentration 0.5-2.0 hrs
||Oral solution (dilute with equal volume of mineral oil)
||Effect in 20 mins; peak concentration 2.5 hrs
||Moderate cathartic effect; use glass syringe
||Peak concentration 4-5hrs; 90% absorbed
||Onset may be too slow for acute use.
||Peak concentration 0.5-1.5 hrs
|Maintenance||Same as oral||Same as acute||Same as acute||  |
||Oral solution (dilute with equal volume of water)
||Peak concentration 1-3 hrs
|Maintenance||Same as oral||Valproic acid liquid from capsules mixed into Supocire C lipid base||Peak concentration 2-4 hrs; 80% absorbed||  |
*Extemporaneously prepared using commercial products; all other preparations are commercial products given rectally.
Adapted from NM Graves, AL Kriel. Rectal administration of antiepileptic drugs in children. Pediatric Neurol 1987;3:321-326. These data are based largely on pediatric studies.