Author: CF Lacy, LL Armstrong, MP Goldman
Support information on page: Infectious States & Seizures > Seizure complications of antibacterial treatment and Infectious States & Seizures > Viral infections > Human immunodeficiency virus (HIV)
Cyto-
chrome P-450 Iso-
enzyme |
Antimicrobial |
Anticonvulsant |
| Substrate |
Inducer |
Inhibitor |
Substrate |
Inducer |
Inhibitor |
| 1A2 |
Ritonavir |
Rifampin |
Ciprofloxacin |
Diazepam |
Carba-
mazepine |
|
| Ritonavir |
Clarithromycin |
Pheno-
barbital |
| Erythromycin |
Phenytoin |
| Isoniazid |
Primidone |
| Ketoconazole |
| Levofloxacin |
| Ritonavir |
| 2A6 |
Ritonavir |
|
Ritonavir |
|
Pheno-
barbital |
|
| 2B6 |
|
|
|
|
Pheno-
barbital |
|
| Phenytoin |
| Primidone |
| 2C |
|
Rifampin |
Isoniazid |
|
Carba-
mazepine |
|
| Ketoconazole |
Pheno-
barbital |
| Phenytoin |
| Primidone |
| 2C8 |
|
Rifampin |
|
Carba-
mazepine |
Carba-
mazepine |
|
| Diazepam |
Pheno-
barbital |
| Phenytoin |
| Primidone |
| 2C9 |
Dapsone |
Fluconazole |
Chlora-
mphenicol |
Phenytoin |
Carba-
mazepine |
Valproic acid |
| Metronidazole |
Rifampin |
Isoniazid |
Pheno-
barbital |
| Ritonavir |
Ketoconazole |
Phenytoin |
| Metronidazole |
| Ritonavir |
Sulamethox
axole
trimethoprim |
| Sulfonamides |
| 2C18 |
|
Rifampin |
|
|
Carba-
mazepine |
|
Pheno-
barbital |
| Phenytoin |
| 2C19 |
Pentamidine |
Rifampin |
Fluconazole |
Pheno-
barbital |
Carba-
mazepine |
Felbamate |
| Ritonavir |
Isoniazid |
Phenytoin |
Pheno-
barbital |
Oxcarbaz-
epine |
| Ketoconazole |
Topiramate |
Phenytoin |
Topiramate |
| Ritonavir |
Valproate |
| 2D6 |
|
Chloroquine |
|
Tagabine |
Valproate |
|
| Quinidine |
| Ritonavir |
| 2E1 |
Dapsone |
Isoniazid |
Ritonavir |
|
|
|
| Isoniazid |
| Ritonavir |
| 3A3/4 |
Clarithromycin |
Griseofulvin |
|
Carba-
mazepine |
Carba-
mazepine |
|
| Clindamycin |
Nafcillin |
Clonazepam |
Oxcarb-
azepine |
| Dapsone |
Rifabutin |
Diazepam |
Pheno-
barbital |
| Erythromycin |
Tiagabine |
Phenytoin |
| Indinavir |
Primidone |
| Itraconazole |
| Ketoconazole |
| Miconazole |
| Nelfinavir |
| Quinidine |
| Rifamipin |
| Ritonavir |
| Saquinavir |
| 3A5-7 |
Quinidine |
Rifampin |
Clotrimazole |
|
Pheno-
barbital |
|
| Ketoconazole |
Phenytoin |
| Metronidazole |
Primidone |
Data adapted from CF Lacy, LL Armstrong, MP Goldman. Drug Information Handbook. Hudson, OH: Lexi-Comp, 2000; 1092-1100; P Hantson, F Leonard, JM Maloteaux, P Maheiu. How epileptogenic are the recent antibiotics? Acta Clin Belg 1999; 54:80-87
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