Author: BS Koppel
Support information on page: Drugs & Their Contribution to Seizures > Antipsychotic
| Generic name | Brand name | Metabolism |
| haloperidol | Haldol | CYP2D6/3A4 |
| perphenazine | Trilafon | CYP2D6 |
| chlorpromazine | Thorazine | CYP2D6, GT1A4 |
| thioridazine | Mellaril | CYP2D6 |
| thiothixene | Navane | CYP2D6 |
| trifluoperazine | Stelazine | |
| Atypical antipsychotics |
|---|
| clozapine | Clozaril | CYP1A2/3A4, GT1A3/4 |
| risperidone | Risperdal | CYP2D6 |
| olanzapine | Zyprexa | CYP1A2 |
| quetiapine | Seroquel | CYP3A |
CYP = cytochrome P-450; GT = glucuronosyltransferase.
Adapted from: Koppel BS. Contribution of drugs and drug interactions (prescribed, over the counter, and illicit) to seizures and epilepsy. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;163.
With permission from Elsevier (www.elsevier.com).
Reviewed March 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.
