Support information on page: Antidepressants

Generic name	Brand name	Metabolism
Tricyclic antidepressants
amitriptyline	Elavil	CYP1A2/2D6, GT1A1
imipramine	Tofranil	CYP1A2/2C19, GT1A3
clomipramine	Anafranil	CYP1A2/2C19/2D6
desipramine	Norpramin	CYP2D6
doxepin	Sinequan	GT1A3/1A4
nortriptyline	Pamelor	CYP2D6
trimipramine	Surmontil
Selective serotonin reuptake inhibitors (SSRIs)
citalopram	Celexa	CYP2C19/2D6
fluoxetine	Prozac	CYP2D6/3A3/4
fluvoxamine	Luvox	CYP1A2/others
paroxetine	Paxil	CYP2D6/others
sertraline	Zoloft	CYP3A3/4
Monoamine oxidase inhibitors (MAOIs)
phenelzine	Nardil
tranylcypromine	Parnate
Others
maprotiline	Ludomil
amoxapine	Asendin
bupropion	Wellbutrin	CYP2B1/2D6/3A4
mirtazapine	Remeron	CYP2D6
nefazodone	Serzone	CYP3A3/4
trazodone	Desyrel
venlafaxine	Effexor	CYP2D6
reboxetine	Vestra	CYP3A4

CYP = cytochrome P-450; GT = glucuronosyltransferase.

Adapted from: Koppel BS. Contribution of drugs and drug interactions (prescribed, over the counter, and illicit) to seizures and epilepsy. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;163.
With permission from Elsevier (www.elsevier.com).
Reviewed March 2004 by Steven C. Schachter, MD, epilepsy.com Editorial Board.