Author: SC Schachter
Support information on page: Treatment > 9 steps of treament > 7 - Interaction awareness
carbamazepine (Tegretol, Tegretol-XR, Carbatrol)
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| chloramphenicol | none |
| erythromycin |
| fluoxetine |
| isoniazid |
| propoxyphene |
| verapamil |
gabapentin (Neurontin)
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| none | antacids (Maalox TC) |
lamotrigine (Lamictal)
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| sertraline (based on a case report only) | oral contraceptives |
levetiracetam (Keppra)h3
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| none | none |
phenobarbital
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| isoniazid | none |
phenytoin (Dilantin, Phenytek)
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| 5-FU | antacids |
| allopurinol | ASA (total phenytoin concentrations
may decrease due to protein-binding
displacement, but unbound concentrations
should remain unaltered) |
| amiodarone |
| chloramphenicol |
| cimetidine |
| diltiazem | carmustine |
| disulfiram | ethanol (chronic ingestion) |
| fluconazole | folate (high dose) |
| fluoxetine | methotrexate |
| ibuprofen | rifampin |
| imipramine | sucralfate |
| INH | vinblastine |
| methylphenidate | |
| metronidazole | |
| omeprazole | |
| propoxyphene | |
| ritonavir | |
| ticlopidine | |
| trimethoprim/sulfa |
topiramate (Topamax)
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| none | none |
valproate (Depakote, Depakote ER, Depakene, valproic acid)
| Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
| acetylsalicylic acid (ASA) | none |
| isoniazid |
Adapted from: Schachter SC. Treatment of seizures. In: Schachter SC, Schomer DL, eds. The comprehensive evaluation and treatment of epilepsy. San Diego, CA: Academic Press; 1997. p. 61-74.
With permission from Elsevier (www.elsevier.com).
Reviewed and revised February 2004 by Barry Gidal, PharmD, University of Wisconsin-Madison.
