PUB. NUMBER  

EP2068933

Appl. Data  

EP2007837400A 20070827

JAZZ PHARMACEUTICALS INC

JAMIESON, Gene

DES JARDIN, Michael

ALLPHIN, Clark

OLAFSDOTTIR, Sigridur

TITLE  

PHARMACEUTICAL COMPOSITIONS OF CLONAZEPAM AND METHODS OF USE THEREOF

ABSTRACT  

The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is soluble, the first solvent capable of penetrating nasal mucosal tissue, and a second solvent in which the benzodiazepine in less soluble. The compositions of the present invention may be used to treat a variety of disorders including, but not limited to, panic attacks, muscle spasms, anxiety, and seizures. In one aspect, the present invention relates to a fast-acting, clonazepam composition for transnasal administration that can be used for the treatment of seizure clusters.

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