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Scientists at Yeungnam University, Medical Department target adult onset still disease

Immunotherapy Weekly via NewsEdge :

2008 JUL 23 - (NewsRx.com) -- "Prolonged spiking fever, an evanescent salmon-colored rash, arthralgia or arthritis, leukocytosis and organ dysfunction are characteristic of adult onset Still's disease (AOSD) (see also Adult Onset Still Disease). A 25-year-old woman with fever lasting over 3 weeks presented to our clinic," researchers in South Korea report.

"The patient had a spiking fever, sore throat, tender lymph nodes, a fine pink-colored skin rash, arthralgia, myalgia with a high ESR, ferritin and elevated hepatic enzymes. NSAID and prednisolone were prescribed for AOSD with SIRS. After 4 days of therapy, with mild confusion, the patient went into status epilepticus lasting several hours and died after cardiovascular collapse. There has been only one case of status epilepticus associated with AOSD in the medical literature," wrote Y.H. Hong and colleagues, Yeungnam University, Medical Department.

The researchers concluded: "Here we report a case of AOSD with SIRS complicated by fatal status epilepticus."

Hong and colleagues published their study in Rheumatology International (A case of adult onset Still's disease with systemic inflammatory response syndrome complicated by fatal status epilepticus. Rheumatology International, 2008;28(9):931-933).

For additional information, contact C.K. Lee, Yeungnam University, College Medical, Dept. of Internal Medical, Taegu, South Korea.

Publisher contact information for the journal Rheumatology International is: Springer, 233 Spring St., New York, NY 10013, USA.

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