Pain & Central Nervous System Week via NewsEdge :

2008 JUL 7 - (NewsRx.com) -- According to a study from the United States, "Abnormalities in GABA levels in the central nucleus of the inferior colliculus (CNIC) of the epilepsy-prone hamster (GPG/Vall) were evaluated by using immunohistochemistry, densitometry and high performance liquid chromatography (HPLC)."

"These findings demonstrate a decrease both in GABA immunostaining (neuropil and neurons) and in GABA concentration (HPLC) in the CNIC of the epileptic hamster compared to control animals," wrote V (see also Epilepsy). Fuentessantamaria and colleagues, Wake Forest University, Medical Department.

The researchers concluded: "These decreases may reflect a reduced availability of this neurotransmitter that may act as an audiogenic seizure-initiating factor."

Fuentessantamaria and colleagues published the results of their research in Epilepsy Research (Decreased levels of GABA In the inferior colliculus of the epilepsy-prone hamster (GPG/Vall). Epilepsy Research, 2008;79(2-3):224-227).

For additional information, contact V. Fuentessantamaria, Wake Forest University, Bowman Gray School Medical, Dept. of Neurobiology & Anatomy, 300 S Hawthorne Rd., Winston Salem, NC 27157, USA.

The publisher of the journal Epilepsy Research can be contacted at: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

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