Dosing and titration of Trileptal
Adults usually are started with 300 to 600 mg per day, divided into two doses. The dose can be increased after about a week. The recommended dosage as monotherapy in adults is 600 to 1,200 mg per day, in two doses. Higher dosages may be necessary when used as polytherapy in patients with refractory seizures. MHD levels of 10-30 mcg/mL are usually attained.
Doses should be reduced by half for patients with renal insufficiency.
