References
Abstracts of articles relevant to this topic are available through PubMed, a service of the National Library of Medicine:
Here are links to some articles relevant to this subject:
Biton V, Montouris GD, Ritter F, et al. A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures. Topiramate YTC Study Group. Neurology 1999 Apr 22;52(7):1330-7. PMID: 10227614.
Topamax was effective as add-on therapy for primary generalized seizures in both adults and children, and side effects were not a serious problem.
Cramer JA, Ben Menachem E, French J. Review of treatment options for refractory epilepsy: new medications and vagal nerve stimulation. Epilepsy Res 2001 Nov;47(1-2):17-25. PMID: 11673017.
In a number of research studies, Topamax was more successful than six other new seizure medicines in controlling partial seizures as add-on therapy, but it had a higher rate of unwanted side effects at high doses.
Guberman A, Neto W, Gassmann-Mayer C; EPAJ-119 Study Group. Low-dose topiramate in adults with treatment-resistant partial-onset seizures. Acta Neurol Scand 2002;106:183-189. PMID: 12225311.
Topamax was effective and well tolerated as adjunctive therapy when added to carbamazepine (an enzyme-inducing AED) at a dosage of 200 mg/day.
Crawford P. An audit of topiramate use in a general neurology clinic. Seizure 1998 Jun;7(3):207-11. PMID: 9700833.
Khan A, Faught E, Gilliam F, Kuzniecky R. Acute psychotic symptoms induced by topiramate. Seizure 1999 Jun;8(4):235-7. PMID: 10452922.
Mula M, Trimble MR, Lhatoo SD, Sander JW. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia 2003 May;44(5):659-63. PMID: 12752464.
Reife RA, Pledger GW: Topiramate as adjunctive therapy in refractory partial epilepsy: pooled analysis of data from five double-blind, placebo-controlled trials. Epilepsia 38 Suppl 1: S31, 1997. PMID 9092956.
Sachdeo RC, Glauser TA, Ritter F, et al. A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Topiramate YL Study Group. Neurology 1999 Jun 10;52(9):1882-7. PMID: 10371538.
Trimble MR, Rusch N, Betts T, Crawford PM. Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables. Seizure 2000 Jun;9(4):249-54. PMID: 10880283.
