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Tegretol®
Diagnosis & Treatment > Seizure Medications > Tegretol® > Interactions with other medications
 

Interactions with other medications

Effects of carbamazepine on other drugs
Because carbamazepine accelerates hepatic metabolism, it will increase the clearance of:

  • oral contraceptives
  • valproate
  • phenytoin
  • phenobarbital
  • primidone
  • clonazepam
  • topiramate
  • ethosuximide
  • corticosteroids
  • warfarin
  • antipsychotics
  • cyclosporine

Effects of other drugs on carbamazepine
Drugs that will increase the serum concentration of carbamazepine by inhibiting its hepatic metabolism include:

  • valproate
  • cimetidine
  • dextropropoxyphene
  • diltiazem
  • erythromycin
  • isoniazid
  • verapamil
  • viloxazine
  • fluconazole, ketoconazole, metronidazole, nefazodone
  • fluoxetine
Grapefruit juice has a similar effect.

Taking carbamazepine simultaneously with lamotrigine may increase the likelihood of neurotoxic side effects. Staggering the doses of carbamazepine and lamotrigine by 1 to 2 hours may lessen this effect.

On the other hand, drugs that accelerate hepatic metabolism will lower serum concentrations of carbamazepine. These include:

  • phenytoin
  • oxcarbazepine
  • phenobarbital
  • primidone
  • felbamate

AED Interaction Sheets:
Seizure drugs are often affected by drug-drug interactions. Print these informative sheets for practical help.