Dosing and titration of Neurontin
Dosing in patients with normal renal function should be initiated at 300 mg a day and increased by 300 mg (in 3 or 4 divided doses) every 1 to 3 days to the maximum tolerated dose.
The recommended dosage as add-on therapy ranges from 900 to 1800 mg daily, but many patients need higher dosages for efficacy. Doses are generally given three times a day, with no more than 12 hours between doses.
A therapeutic serum concentration range has not been established.
