References
Abstracts of articles relevant to this topic are available through PubMed, a service of the National Library of Medicine:
Mattson, RH, Cramer, JA, et al. Comparison of carbamazepine, phenobarbital, phenytoin and primidone in partial and secondarily generalized tonic clonic seizures. N Engl J Med. 1985;313:145-151. PMID: 3925335.
Primidone (Mysoline) was as effective as the other medications for generalized tonic-clonic seizures in adults, but the patients who took it experienced many more intolerable side effects in the early weeks of treatment.
Herranz JL, Armijo JA, Arteaga R. Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children. Epilepsia. 1988;29(6):794-804. PMID: 3142761.
Children taking primidone (Mysoline) had a low rate of overall side effects and a moderate rate of withdrawal from treatment due to side effects in comparison to the other medications tested.
