Clinical pharmacology of Klonopin
Klonopin is metabolized in the liver by the cytochrome P-450 system and the metabolites are excreted by the kidneys. Klonopin is approximately 85% protein bound.
Klonopin is rapidly and nearly completely absorbed following oral administration. Peak serum concentrations are reached in approximately 1-4 hours. The half-life of Klonopin in multiple dose studies is approximately 30-40 hours. The effects of age, gender, hepatic dysfunction and renal dysfunction on the pharmacokinetics of Klonopin have not been well studied.
