Dosing and titration of Keppra
Treatment in adults can be initiated at 500 mg twice daily. This was an effective dose in the controlled trials. The dosage can be titrated by 1,000 mg every two weeks, up to 4,000 mg daily as needed for seizure control.
Doses in patients with renal insufficiency should be reduced by 50%.
Therapeutic blood levels have not been established. Dosage adjustments should depend on clinical response.
