Abstracts of articles relevant to this topic are available through PubMed, a service of the National Library of Medicine:
Here are links to some articles relevant to this subject:
Brodie MJ. Tiagabine pharmacology in profile. Epilepsia 1995;36(suppl 6):S7-S9. PMID: 8595791.
Lassen LC, Sommerville K, Mengel HB, et al. Summary of five controlled trials with tiagabine as adjunctive treatment of patients with partial seizures. Epilepsia 1995;36(suppl 3):S148.
Leppik IE, Gram L, Deaton R, et al. Safety of tiagabine: summary of 53 trials. Epilepsy Res 1999;33:235-246. PMID: 10094434.
Sachdeo RC, Leroy RF, Krauss GL, et al. Tiagabine therapy for complex partial seizures. A dose-frequency study. The Tiagabine Study Group. Arch Neurol 1997 May;54(5):595-601. PMID: 9152116.
Gabitril given as add-on therapy 2 or 4 times per day was effective in reducing complex partial seizures.
Schachter SC. Tiagabine monotherapy in the treatment of partial epilepsy. Epilepsia 1995;36 Suppl 6:S2-S6. PMID: 8595789.
Gabitril used alone may be helpful in controlling partial seizures for some patients who have not achieved good control with other antiepileptic medications.
Schachter SC, Deaton R, Sommerville K. Long-term use of tiagabine for partial seizures. Epilepsia 1997;38(suppl 8):S105-S106.
Schmidt D, Gram L, Brodie M, et al. Tiagabine in the treatment of epilepsy---a clinical review with a guide for the prescribing physician. Epilepsy Res 2000;41:245-251. PMID: 10962215.
Shinnar S, Berg AT, Treiman DM, et al. Status epilepticus and tiagabine therapy: review of safety data and epidemiologic comparisons. Epilepsia 2001;42:372-379. PMID: 11442155.
Striano S, Striano P, Boccella P, et al.. Tiagabine in glial tumors. Epilepsy Res 2002;49:81-85. PMID: 11948010.
Suzdak PD, Jansen JA. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 1995;36:612-626. PMID: 7555976.
Uthman BM, Rowan AJ, Ahmann PA, et al. Tiagabine for complex partial seizures: a randomized, add-on, dose-response trial. Arch Neurol 1998 Jan;55(1):56-62. PMID: 9443711.
Gabitril given as add-on therapy at various doses was effective in reducing complex partial seizures. Higher doses were more effective.
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