Interactions with other medications
Effects of Gabitril on other drugs
Even though the protein binding of Gabitril is 96%, it does not displace other drugs that are tightly bound to albumin. Likewise, Gabitril does not affect the metabolism of other drugs. Therefore, Gabitril has no appreciable effect on other drugs.
Low doses of Gabitril (8 mg/day) have no effect on the metabolism of oral contraceptives, but whether higher doses have an effect is unknown.
Effects of other drugs on Gabitril
Gabitril is metabolized by the hepatic isoenzyme CYP3A, so drugs that induce this isoenzyme increase its clearance. If concomitantly administered enzyme-inducing AEDs are discontinued, the half-life of Gabitril will decrease and serum concentrations may rise.
The AEDs that decrease the blood level of Gabitril are:
- carbamazepine (Tegretol, Carbatrol)
- primidone (Mysoline)
- phenytoin (Dilantin, Phenytek)
AED Interaction Sheets:
Seizure drugs are often affected by drug-drug interactions. Print these informative sheets for practical help.