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Gabitril®
 

Efficacy of Gabitril

In several randomized, controlled clinical trials, Gabitril was significantly more effective than a placebo for patients with frequent partial seizures. In two studies, 20-31% of the patients who took Gabitril reduced their seizure frequency by half or more, without excessive adverse side effects (Sachdeo et al. 1997; Uthman et al. 1998).

In other studies, approximately 1,200 patients received Gabitril for 1 year or more in 6 trials (Schachter et al.1997). Complex partial seizure rates declined by a median of 28% after 3 to 6 months of treatment and 44% after treatment for at least one year. Seizure reductions were maintained up to 24 months.

No single combination of antiepileptic medications is perfect for everyone. Sometimes, a series of combinations must be tried before finding what is best for the individual patient. Some other medications affect the rate at which Gabitril is eliminated from the body, so the dosages may need to be changed with different combinations. See Interactions for more information.

Some smaller studies have indicated that Gabitril also may be effective when used alone to treat partial seizures (Schachter 1995). It is rarely used as monotherapy, however.