Children and Gabitril
Children and Gabitril (tiagabine)
When adjusted for body weight, the elimination of Gabitril is two times higher in children than in uninduced adults with epilepsy.
Dosages in children have not been well established. In one pediatric trial, dosages up to 0.4 mg/kg were used for children with uninduced hepatic function. Dosages up to 0.7 mg/kg were used for children taking enzyme-inducing AEDs.
Children usually start with a dose of 0.1 mg/kg per day. This is usually given in 2 or 3 divided doses. Most children do best at about 0.1 to 2 mg/kg per day given in two to four doses.
