Clinical pharmacology of Diastat
Diastat is well absorbed following rectal administration and reaches peak plasma concentrations in 1.5 hours. The half-life in adults is approximately 46 hours. Diazepam and its major active metabolite desmethyldiazepam are over 95% protein-bound.
Diazepam is metabolized in the liver by the CYP3A4 and CYP2C19 isoenzymes to one major active metabolite (desmethyldiazepam) and two minor active metabolites.
