Clinical pharmacology of Keppra XR
Absorption
Keppra XR is rapidly and nearly completely absorbed after oral administration. Peak serum concentrations with both the tablets and liquid form are achieved in about 1 hour when Keppra XR is taken without food and 2 hours with food. Daily doses and plasma concentrations are linearly related.
Distribution and metabolism
Keppra XR is not protein bound (<10%) and the major metabolic pathway is hydrolysis of the acetamide group to the inactive carboxylic derivative.
Steady state
In children and adults, steady state is achieved after two days of twice-daily dosing.
