Clinical pharmacology of Keppra
Keppra is rapidly and nearly completely absorbed after oral administration. Peak serum concentrations with both the tablets and liquid form are achieved in about 1 hour when Keppra is taken without food and 2 hours with food. Daily doses and plasma concentrations are linearly related.
Distribution and metabolism
Keppra is not protein bound (<10%) and the major metabolic pathway is hydrolysis of the acetamide group to the inactive carboxylic derivative.
In children and adults, steady state is achieved after two days of twice-daily dosing.