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Topamax®

Diagnosis & Treatment > Seizure Medications > Topamax® > Mechanisms of action of Topamax

Mechanisms of action of Topamax

Topamax has multiple mechanisms of action:

• blocking voltage-dependent sodium channels
• enhancing GABA activity at a nonbenzodiazepine site on GABA(A) receptors
• antagonizing an NMDA–glutamate receptor
• weakly inhibiting carbonic anhydrase in the central nervous system

Select medication Carbamazepine Clobazam Clonazepam Carbatrol® Depakene® Depakote® Depakote ER® Diastat Dilantin® Felbatol® Frisium Gabapentin Gabitril® Inovelon® Keppra® Keppra XR™ Klonopin Lamictal® Lyrica Mysoline® Neurontin® Oxcarbazepine Perampanel Phenobarbital Phenytek® Phenytoin Potiga Rufinamide Sabril Tegretol® Tegretol XR® Topamax® Trileptal® Valproic Acid Vimpat Zarontin® Zonegran Zonisamide

Advanced Information
	Introduction to Topamax
	Indications for Topamax
	Mechanisms of action of Topamax
	Mechanisms of action of Topamax
	Clinical pharmacology of Topamax
	Efficacy of Topamax
	Common side effects of Topamax
	Serious side effects of Topamax
	Other uses of Topamax
	Contraindications for Topamax
	Interactions of Topamax with other medications
	Children and Topamax
	Pregnancy and Topamax
	Seniors and Topamax
	Dosing and titration of Topamax
	Package insert
	References